Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX
Answer: There are no specific UK guidelines that explicitly advise against the use of levomepromazine in palliative care for patients with epilepsy. Levomepromazine is recommended in palliative care as a second- or third-line anti-emetic due to its sedative effects, with no direct contraindications mentioned regarding epilepsy in the available UK guidance.
However, careful consideration should be given to the potential sedative and neurological side effects of levomepromazine, especially in patients with epilepsy, to avoid lowering seizure threshold or exacerbating seizure control. Specialist consultation is advised if there is concern about interactions or adverse effects in people with epilepsy.