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Recommended mx for acute sinusitis in primary care, including when to prescribe
Answer
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 23 November 2025
Recommended management for acute sinusitis in primary care:
- Most cases of acute sinusitis are viral and self-limiting, resolving within 12 weeks without antibiotics. Advise patients that bacterial sinusitis is usually self-limiting and does not routinely require antibiotics.
- Offer symptomatic treatment with paracetamol or ibuprofen for pain or fever relief.
- Consider nasal saline irrigation or nasal decongestants for nasal congestion, although evidence for their effectiveness is limited.
- For adults and children aged 12 years and over, a high-dose nasal corticosteroid (e.g., mometasone 200 micrograms twice daily for 14 days) may be considered to improve symptoms, but it is unlikely to shorten illness duration.
- Do not routinely prescribe oral corticosteroids, oral decongestants, antihistamines, mucolytics, steam inhalation, or warm face packs as these are not recommended due to lack of evidence of benefit.
- Antibiotic prescribing guidance:
- Do not routinely prescribe antibiotics for acute sinusitis.
- Consider a back-up (delayed) antibiotic prescription if symptoms persist beyond 10 days, or if there is a marked deterioration after an initial milder phase ("double sickening"), or if symptoms are severe (e.g., fever >38°C, severe localized unilateral pain, discoloured or purulent nasal discharge).
- Immediate antibiotic prescription is reserved for patients who are systemically very unwell, have signs of a more serious illness, or are at high risk of complications due to comorbidities or immunosuppression.
- If antibiotics are indicated in adults, phenoxymethylpenicillin 500 mg four times daily for 5 days is the first-line treatment.
- Advise patients given a back-up antibiotic to start it only if symptoms do not improve within 7 days or worsen rapidly or significantly at any time.
- Reassess patients if symptoms worsen rapidly or significantly despite treatment, considering alternative diagnoses and referral to specialists if needed.
Provide written advice and safety-netting information, including when to seek further medical help if symptoms worsen or do not improve after 3 weeks.
This approach balances effective symptom management with antimicrobial stewardship to reduce unnecessary antibiotic use and adverse effects.
References: 1,8
Key References
- CKS - Sinusitis
- Phenoxymethylpenicillin SmPC
- Ceftazidime with avibactam SmPC
- Fluticasone SmPC
- NG237 - Suspected acute respiratory infection in over 16s: assessment at first presentation and initial management
- Mometasone furoate SmPC
- Clarithromycin SmPC
- NG15 - Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use
- NG147 - Diverticular disease: diagnosis and management
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