Contraindications for medroxy progesterone

Contraindications for the use of medroxyprogesterone acetate include:

• General contraindications: acute porphyrias and current breast cancer (unless progestogens are being used in the management of this condition).
• Specific contraindications with oral use: history of thromboembolism and undiagnosed vaginal bleeding.
• When used for contraception: current or history of meningioma.

High-dose medroxyprogesterone acetate (all parenteral preparations and oral preparations containing 100 mg or more) is contraindicated in patients with meningioma or a history of meningioma; if meningioma is diagnosed during treatment, the drug must be stopped.

These contraindications are based on safety concerns including thromboembolic risk, cancer risk, and undiagnosed bleeding that may indicate underlying pathology.

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