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What are the key clinical features that should raise suspicion for a bone or soft tissue sarcoma in a patient?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 22 August 2025
Key clinical features raising suspicion for bone or soft tissue sarcoma include:
- An unexplained lump that is increasing in size, particularly in children and young people, which should prompt consideration of soft tissue sarcoma and urgent ultrasound within 48 hours.
- Persistent or unexplained bone pain in children and young people, which should raise suspicion of bone sarcoma and prompt urgent X-ray within 48 hours.
- In adults, an X-ray suggesting the possibility of bone sarcoma warrants a suspected cancer pathway referral.
These features should be considered alongside any associated symptoms such as weight loss, fever, or night sweats, which may further support the need for urgent referral.
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