What are the recommended screening tests for iron overload in patients with a history of multiple blood transfusions?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Recommended screening tests for iron overload in patients with a history of multiple blood transfusions include routine monitoring of serum ferritin levels at intervals of 1 to 3 months to prevent iron overload. Serum ferritin is the primary test used to monitor iron stores in these patients.

While the provided guidelines focus on monitoring iron status in anaemia and chronic kidney disease, the recommendation to use serum ferritin for routine monitoring of iron stores applies broadly to prevent iron overload in patients receiving multiple transfusions.

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