What criteria should I use to refer a patient for specialist assessment in cases of male infertility?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Criteria for referring a male patient for specialist assessment in cases of infertility include:

  • Men with abnormal semen analysis results, such as azoospermia or other significant semen abnormalities, should be referred for specialist assessment to determine underlying causes and appropriate management options.
  • Men with hypogonadotrophic hypogonadism should be referred as they may benefit from gonadotrophin therapy to improve fertility.
  • Men with obstructive azoospermia should be referred to centres with appropriate expertise for possible surgical correction of epididymal blockage as an alternative to surgical sperm recovery and IVF.
  • Men with chronic viral infections such as hepatitis B, hepatitis C, or HIV should be referred to specialist centres with expertise in safe risk-reduction investigation and treatment before conception is considered.
  • Men with ejaculatory failure or other specific male factor infertility issues should be referred for specialist evaluation and management.

Referral should also be considered earlier if there is a known clinical cause or history of predisposing factors for infertility, or if treatment that may impair fertility (e.g., cancer treatment) is planned.

Routine use of ineffective treatments such as anti-oestrogens, androgens, or surgery for varicoceles is not recommended without specialist assessment.

Overall, referral is indicated when initial assessment including semen analysis suggests male factor infertility or when clinical history indicates a need for specialist input to guide management and treatment options.

References:

Educational content only. Always verify information and use clinical judgement.