Which diagnostic tests are recommended for evaluating suspected non-allergic food sensitivities in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For evaluating suspected non-allergic food sensitivities (non-IgE-mediated food allergy) in adults, the recommended diagnostic approach is primarily clinical and involves an allergy-focused history followed by a trial elimination diet of the suspected allergen for 2–6 weeks, with subsequent reintroduction to observe symptom changes.

No specific diagnostic tests such as skin prick tests or specific IgE antibody blood tests are recommended for non-IgE-mediated food allergy, as these tests are used to identify IgE-mediated allergies.

Alternative diagnostic tests like serum-specific IgG testing, vega test, applied kinesiology, and hair analysis are not recommended for diagnosing food allergy or sensitivities.

Referral to a dietitian with appropriate competencies is advised to ensure nutritional adequacy during elimination and reintroduction phases.

Educational content only. Always verify information and use clinical judgement.