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What are the potential complications of erythroderma that I should monitor for in my patients?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 22 August 2025
Potential complications of erythroderma to monitor for include:
- Secondary bacterial infections, which may present with weeping, pustules, crusts, rapidly worsening skin condition, fever, and malaise. These infections often involve Staphylococcus and Streptococcus species and require prompt recognition and treatment to prevent systemic spread.
- Herpes simplex virus infection (eczema herpeticum), characterized by rapidly worsening painful skin, clustered blisters resembling cold sores, punched-out erosions, fever, lethargy, or distress. This requires urgent systemic antiviral treatment and specialist referral.
- Fluid and electrolyte imbalance due to extensive skin involvement and impaired barrier function, which can lead to dehydration and systemic complications.
- Thermoregulatory dysfunction because of widespread skin inflammation and loss of normal skin function, potentially causing hypothermia or hyperthermia.
- Potential systemic complications such as sepsis, which can arise from untreated or severe infections.
Close monitoring for these complications is essential in patients with erythroderma to ensure timely intervention and specialist referral when indicated.
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