What are the recommended first-line treatments for nocturnal enuresis in children according to NICE guidelines?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The NICE guidelines recommend that first-line treatment for nocturnal enuresis in children includes the use of an alarm and/or desmopressin, especially if previous courses have not been effective .

For children who have not responded to these initial treatments, further review and assessment are advised to identify factors associated with poor response, such as an overactive bladder or social and emotional factors .

Additionally, behavioral interventions such as dry-bed training are not recommended as first-line treatments .

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