What are the recommended first-line treatment options for patients diagnosed with depersonalisation disorder?

Recommended first-line treatment options for depersonalisation disorder:

There are no specific UK NICE guidelines provided in the supplied context that directly address first-line treatment options for depersonalisation disorder. However, depersonalisation disorder is generally considered a dissociative disorder and often comorbid with anxiety and depression. Given this, treatment approaches often align with those for anxiety and depressive disorders, focusing primarily on psychological therapies.

Psychological therapies such as cognitive behavioural therapy (CBT) are typically considered first-line treatments for dissociative symptoms including depersonalisation, aiming to improve coping strategies and reduce distress.

Medication is not routinely recommended as a first-line treatment for depersonalisation disorder, but may be considered if comorbid anxiety or depression is present, following guidelines for those conditions.

Referral to specialist mental health services should be considered if symptoms are severe, persistent, or if initial treatments in primary care are ineffective.

In summary, first-line treatment for depersonalisation disorder primarily involves psychological therapies, with medication considered based on comorbidities and specialist referral as needed.