In managing medication adjustments for a patient undergoing deep brain stimulation (DBS) for movement disorders such as advanced Parkinson's disease, it is essential to coordinate closely with a specialist experienced in Parkinson's disease management. Medication should not be withdrawn abruptly to avoid risks such as acute akinesia or neuroleptic malignant syndrome. Adjustments to antiparkinsonian medicines should be made cautiously and only after specialist consultation, especially in the context of DBS therapy. DBS is considered for patients whose symptoms are not adequately controlled by best medical therapy, and medication regimens often require careful tailoring post-DBS to optimize symptom control and minimize side effects. Regular clinical monitoring and medication adjustments should be supported by a Parkinson's disease nurse specialist or a healthcare professional with expertise in Parkinson's disease. This multidisciplinary approach ensures safe and effective medication management alongside DBS treatment.
How should I manage medication adjustments for a patient undergoing deep brain stimulation for movement disorders?
Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.
Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX