What are the recommended first-line treatments for managing acute attacks of calcium pyrophosphate deposition disease (CPPD)?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

First-line treatments for managing acute attacks of calcium pyrophosphate deposition disease (CPPD) include non-steroidal anti-inflammatory drugs (NSAIDs), colchicine, and short courses of oral corticosteroids.

These treatments are recommended taking into account the person's comorbidities, co-prescriptions, and preferences.

If NSAIDs and colchicine are contraindicated, not tolerated, or ineffective, intra-articular or intramuscular corticosteroid injections may be considered.

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