What are the recommended first-line treatments for uncomplicated urethritis in adults?

Recommended first-line treatments for uncomplicated urethritis in adults:

• Oral doxycycline 100 mg twice daily for 7 days is generally recommended as first-line treatment for uncomplicated urethritis, particularly when Chlamydia trachomatis infection is suspected or confirmed.
• Alternatively, oral azithromycin 1 g as a single dose, or 500 mg daily for 3 days, may be used, especially if doxycycline is contraindicated or not tolerated.
• For Neisseria gonorrhoeae infection, dual therapy with intramuscular ceftriaxone plus oral azithromycin is recommended, but for uncomplicated urethritis without gonorrhoea, doxycycline or azithromycin alone is appropriate.

These recommendations align with UK clinical practice guidelines for sexually transmitted infections and antimicrobial stewardship principles, although the provided context does not explicitly detail urethritis treatment. The use of doxycycline and azithromycin as first-line agents is standard in UK sexual health management protocols.