What are the key clinical features to consider when diagnosing malaria in a patient returning from a tropical region?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When considering a diagnosis of malaria in a patient returning from a tropical region, the key clinical feature is fever . This is a primary symptom that warrants immediate attention, particularly given that guidelines like NG143 address the assessment of fever . Beyond fever, other common symptoms include chills, sweats, headache, muscle aches (myalgia), and gastrointestinal disturbances . It is crucial to obtain a detailed travel history, specifically inquiring about recent visits to malaria-endemic areas . Malaria can present with a wide range of clinical manifestations, and symptoms can often be non-specific, making a high index of suspicion vital . Therefore, any patient presenting with fever and a history of travel to a tropical region should be promptly investigated for malaria .

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