When considering a diagnosis of malaria in a patient returning from a tropical region, the key clinical feature is fever NICE NG143 Taylor et al. 2010. This is a primary symptom that warrants immediate attention, particularly given that guidelines like NG143 address the assessment of fever NICE NG143. Beyond fever, other common symptoms include chills, sweats, headache, muscle aches (myalgia), and gastrointestinal disturbances Taylor et al. 2010. It is crucial to obtain a detailed travel history, specifically inquiring about recent visits to malaria-endemic areas Taylor et al. 2010Weiland 2023. Malaria can present with a wide range of clinical manifestations, and symptoms can often be non-specific, making a high index of suspicion vital Weiland 2023. Therefore, any patient presenting with fever and a history of travel to a tropical region should be promptly investigated for malaria Weiland 2023.
What are the key clinical features to consider when diagnosing malaria in a patient returning from a tropical region?
Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.
Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX