How can I differentiate between a sprain and a fracture in a patient with an ankle injury?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Differentiating between an ankle sprain and a fracture in a patient presenting with an ankle injury primarily relies on a thorough clinical assessment, although definitive diagnosis often requires imaging .

Key indicators that may suggest a fracture over a sprain include:

  • Inability to bear weight: If the patient cannot bear weight immediately after the injury and in the emergency department, this raises suspicion for a fracture .
  • Localized bony tenderness: Significant tenderness upon palpation over specific bony prominences, such as the posterior edge or tip of either malleolus, the navicular bone, or the base of the fifth metatarsal, is a strong indicator for a potential fracture . Foot fractures are frequently misdiagnosed as ankle sprains, emphasizing the need for careful palpation .
  • Gross deformity: Any visible deformity of the ankle or foot is highly suggestive of a fracture or dislocation .

Both sprains and fractures can present with pain, swelling, and bruising, making initial differentiation challenging based solely on these symptoms .

For a definitive diagnosis, especially when clinical suspicion for a fracture is high based on these criteria, X-rays are typically required . In children, ankle injuries can involve growth plates, and careful evaluation is necessary .

If a fracture is confirmed, management will follow specific guidelines for non-complex or complex fractures ,. Rehabilitation is a crucial part of recovery for both sprains and fractures .

Educational content only. Always verify information and use clinical judgement.