Which laboratory tests are essential for confirming a diagnosis of thyroid storm in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The provided UK guideline, 'Thyroid disease: assessment and management' , does not specifically detail essential laboratory tests for confirming a diagnosis of thyroid storm in a primary care setting.

The guideline focuses on tests for suspected thyroid dysfunction, such as measuring thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free tri-iodothyronine (FT3) . For confirmed thyrotoxicosis, it outlines tests to differentiate between hyperthyroidism with and without hyperthyroidism, including measuring TSH receptor antibodies (TRAbs) and considering technetium scanning . Thyroid peroxidase antibodies (TPOAbs) are also mentioned for children and young people with thyrotoxicosis . However, these are for general thyrotoxicosis and not specifically for the acute, severe presentation of thyroid storm .

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