What initial investigations should I perform in a patient suspected of having cardiac tamponade before referring to secondary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Initial investigations for suspected cardiac tamponade before referral to secondary care include:

  • Clinical assessment: Evaluate vital signs including pulse, blood pressure, and oxygen saturation to assess haemodynamic stability.
  • 12-lead ECG: Perform a resting 12-lead electrocardiogram to detect electrical alternans, low voltage QRS complexes, or other abnormalities suggestive of tamponade or pericardial disease.
  • Chest X-ray: Consider a chest radiograph to identify an enlarged cardiac silhouette or other thoracic pathology.
  • Point-of-care ultrasonography (if available): Use bedside echocardiography to assess for pericardial effusion and signs of cardiac tamponade such as right atrial or right ventricular diastolic collapse.

These investigations help confirm the diagnosis and assess severity, guiding urgent referral to secondary care for definitive management.

Educational content only. Always verify information and use clinical judgement.