How should I manage pain in a patient presenting with major trauma before transfer to secondary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025Updated: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For a patient presenting with major trauma before transfer to secondary care, pain management should begin with regular pain assessment using a scale appropriate for their age, developmental stage, and cognitive function . Medications should be offered to control pain in the acute phase .

Intravenous morphine is the first-line analgesic, and the dose should be adjusted to achieve adequate pain relief . If intravenous access has not been established, the intranasal route for atomised delivery of diamorphine or ketamine can be considered . It is important to note that in February 2016, this was an off-label use of intranasal diamorphine and intranasal ketamine . Ketamine in analgesic doses can be considered as a second-line agent .

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