What are the indications for administering intravenous fluids in a patient with major trauma?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025Updated: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For patients with major trauma, intravenous (IV) fluids are indicated primarily for fluid resuscitation, especially in the presence of haemorrhagic shock ,.

  • Haemorrhagic Shock and Traumatic Brain Injury: If haemorrhagic shock is the dominant condition, restrictive volume resuscitation should continue . However, if a traumatic brain injury is the dominant condition, a less restrictive volume resuscitation approach should be used to maintain cerebral perfusion .
  • Fluid Replacement in Active Bleeding:
    • In pre-hospital settings, crystalloids should only be used to replace fluid volume in patients with active bleeding if blood components are not available .
    • In hospital settings, crystalloids should not be used for patients with active bleeding . For adults (16 or over) with active bleeding, a ratio of 1 unit of plasma to 1 unit of red blood cells should be used for fluid volume replacement . For children (under 16), a ratio of 1 part plasma to 1 part red blood cells, based on the child's weight, should be used . Hospital trusts should also have specific major haemorrhage protocols .
  • General Indicators for Urgent Fluid Resuscitation (applicable to major trauma): A patient may need urgent fluid resuscitation if they show indicators of hypovolaemia, including :
    • Systolic blood pressure less than 100 mmHg .
    • Heart rate more than 90 beats per minute .
    • Capillary refill time more than 2 seconds, or cold peripheries .
    • Respiratory rate more than 20 breaths per minute .
    • A National Early Warning Score (NEWS) of 5 or more .
    • Passive leg raising suggests fluid responsiveness .

IV fluid therapy should only be provided when a patient's needs cannot be met by oral or enteral routes, and it should be stopped as soon as possible .

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