Which medications are commonly associated with the development of SIADH that I should be aware of in my prescribing practices?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In general practice, you should be aware that certain medications are commonly associated with the development of hyponatraemia, which can include cases of Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) . Medications that may cause or provoke hyponatraemia should be stopped where practical .

Specific classes of medications to be aware of include:

  • Thiazide diuretics: These are explicitly mentioned as medications that may cause hyponatraemia .
  • Antipsychotics: These medications may contribute to hyponatraemia . If an antipsychotic cannot be stopped, specialist discussion is recommended regarding monitoring or referral .
  • Antidepressants: When prescribing antidepressant medication for older people, there is an increased risk of hyponatraemia, particularly if there are other risk factors such as concomitant use of diuretics .
  • Diuretics (general): Beyond thiazides, diuretics are broadly mentioned in the context of increasing the risk of hyponatraemia, especially when used with other medications like antidepressants or lithium ,.

Related Knowledge Topics

Educational content only. Always verify information and use clinical judgement.