What are the key clinical features to consider when diagnosing silicosis in a patient with a history of occupational exposure?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When diagnosing silicosis in a patient with a history of occupational exposure, a detailed occupational history, specifically regarding silica exposure, is a primary consideration . A crucial clinical feature to consider is the strong association between silicosis and tuberculosis . Therefore, the presence of symptoms suggestive of tuberculosis, such as chronic cough, fever, night sweats, or unexplained weight loss, should prompt investigation in patients with suspected silicosis . Silicosis is recognised as a significant silica-related disease .

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