What initial investigations should I perform to confirm a diagnosis of pyloric stenosis in a suspected case?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For a suspected case of pyloric stenosis, the initial investigation involves arranging an urgent specialist hospital assessment ,. This assessment should take place on the same day for infants younger than 2 months who present with progressively worsening or forceful (projectile) vomiting of feeds ,. This urgent referral is crucial to assess for and confirm the possible diagnosis of hypertrophic pyloric stenosis ,.

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