Which treatment options are recommended for patients with Peyronie's disease who experience significant penile curvature affecting sexual function?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025Updated: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For patients with Peyronie's disease who experience significant penile curvature affecting sexual function, treatment options primarily focus on surgical correction once the disease is stable .

The main surgical approaches include:

  • Plication procedures are considered for patients with adequate penile length and less severe curvature . This technique involves shortening the longer side of the penis to straighten it .
  • Incision or excision with grafting is an option for more severe curvatures or significant penile shortening, aiming to straighten the penis and potentially restore length . This involves incising or excising the plaque and covering the defect with a graft .
  • Penile prosthesis implantation is typically reserved for patients who also have erectile dysfunction in addition to the curvature . The prosthesis can help straighten the penis while also addressing the erectile dysfunction .

While non-surgical treatments exist, they are generally less effective for significant curvature that impacts sexual function .

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