For a patient diagnosed with a complete molar pregnancy, the primary recommended management strategy involves the evacuation of the mole NICE NG126. This procedure is typically performed via suction curettage NICE NG126.
Following the evacuation, meticulous follow-up is essential due to the significant risk of developing gestational trophoblastic neoplasia (GTN) [1, Seckl et al. 2010]. This follow-up primarily involves the serial monitoring of human chorionic gonadotropin (hCG) levels [1, Seckl et al. 2010]. hCG levels should be monitored until they return to normal and then for a specified period to detect any persistent trophoblastic disease [1, Seckl et al. 2010]. Gestational trophoblastic neoplasia develops in approximately 15-20% of cases of complete moles and often requires chemotherapy for treatment [ Seckl et al. 2010].
Regarding prophylactic measures, some literature explores the use of prophylactic chemotherapy for hydatidiform mole with the aim of preventing gestational trophoblastic neoplasia (GTN) [ Wang et al. 2017].
Key References
- NG126 - Ectopic pregnancy and miscarriage: diagnosis and initial management
- CKS - Ectopic pregnancy
- CKS - Miscarriage
- (Seckl et al., 2010): Gestational trophoblastic disease.
- (National Collaborating Centre for Women's and Children's Health (UK), 2012): No Title Available
- (Wang et al., 2017): Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia.