What diagnostic tests are recommended for confirming a suspected case of CJD in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025Updated: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In a primary care setting, no specific diagnostic tests for confirming Creutzfeldt-Jakob disease (CJD) are recommended. Instead, if CJD is suspected, especially in cases of rapidly progressive dementia, the person should be referred urgently to a neurological specialist service that has access to appropriate diagnostic tests, including cerebrospinal fluid (CSF) examination and other specialized investigations for CJD and similar conditions.

Primary care assessment should focus on identifying reversible causes of cognitive decline and referring the patient to specialist dementia diagnostic services or neurological services as appropriate.

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