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What are the recommended investigations for a patient with suspected ulcerative colitis presenting with diarrhea and abdominal pain?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 16 August 2025
For a patient presenting with suspected ulcerative colitis with symptoms of diarrhea and abdominal pain, the recommended investigations include:
- Blood tests: Full blood count (FBC) to check for anaemia and inflammatory markers such as erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) to assess inflammation levels.
- Stool tests: To exclude infections and other causes of diarrhea.
- Endoscopic evaluation: Flexible sigmoidoscopy or colonoscopy with biopsy is essential to confirm the diagnosis and assess the extent and severity of mucosal inflammation.
- Additional antibody testing: To exclude other conditions such as coeliac disease if clinically indicated.
These investigations help differentiate ulcerative colitis from other causes of diarrhea and abdominal pain and guide appropriate management.
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