What are the current first-line treatment options for managing mild to moderate ulcerative colitis in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For adults with mild to moderate ulcerative colitis, the current first-line treatment options include a topical aminosalicylate as the initial therapy.

If remission is not achieved within 4 weeks, consider adding an oral aminosalicylate.

In cases where further treatment is needed, a time-limited course of corticosteroids may be considered.

Related Knowledge Topics

Educational content only. Always verify information and use clinical judgement.