What are the key clinical features to consider when assessing a patient for mitral stenosis?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When assessing a patient for mitral stenosis, key clinical features to consider include symptoms such as exertional dyspnoea, fatigue, and palpitations due to atrial fibrillation, which are common presentations reflecting impaired left atrial emptying and pulmonary congestion . On examination, a characteristic low-pitched, rumbling diastolic murmur best heard at the apex with the patient in the left lateral position is a hallmark sign, often preceded by an opening snap following the second heart sound, indicating restricted mitral valve leaflet motion . Additional signs may include a loud first heart sound and evidence of pulmonary hypertension such as a loud pulmonary component of the second heart sound . Clinical features may also include signs of right heart failure in advanced disease, such as peripheral oedema and raised jugular venous pressure . Echocardiographic assessment is essential to confirm the diagnosis and evaluate severity, showing thickened mitral leaflets with restricted mobility and reduced mitral valve area, often due to rheumatic heart disease . The literature emphasizes the importance of correlating clinical findings with echocardiographic features to guide management effectively .

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