What are the key diagnostic criteria for acute pancreatitis in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Key diagnostic criteria for acute pancreatitis in primary care include:

  • Sudden onset of upper abdominal pain, typically epigastric, often severe and persistent.
  • Associated symptoms such as nausea and vomiting are common.
  • Physical signs may include epigastric tenderness, fever, and tachycardia.
  • Confirmation of diagnosis is primarily by raised blood levels of pancreatic enzymes, specifically lipase or amylase.
  • If enzyme levels are not elevated but clinical suspicion remains high, abdominal imaging such as CT scan may be used to confirm pancreatic inflammation.
  • Do not delay emergency hospital admission for suspected acute pancreatitis by arranging blood tests or imaging in primary care; immediate specialist assessment is required.

These criteria help identify suspected acute pancreatitis promptly to ensure urgent referral and management.

Educational content only. Always verify information and use clinical judgement.