What are the potential complications of rapid correction of hypernatraemia that I should be aware of?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Potential complications of rapid correction of hypernatraemia include cerebral oedema and neurological damage. Rapid lowering of plasma sodium concentration can cause water to move into brain cells, leading to swelling and increased intracranial pressure. Therefore, the rate of fall of plasma sodium should not exceed 12 mmol/litre in a 24-hour period to avoid these complications. Careful monitoring of plasma electrolytes every 4 to 6 hours during the first 24 hours is essential to guide safe correction and prevent adverse outcomes.

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