What lifestyle modifications should I advise to patients with familial hypercholesterolaemia in addition to pharmacological treatment?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Patients with familial hypercholesterolaemia should be advised to undertake physical activity in line with national guidance, including aerobic and muscle-strengthening activities, such as brisk walking, using stairs, and cycling, or exercising at their maximum safe capacity if unable to perform moderate activity .

They should be encouraged to consume a diet where total fat intake is 30% or less of total energy, saturated fats are less than 7% of total energy, and dietary cholesterol is less than 300 mg/day, replacing saturated fats with monounsaturated and polyunsaturated fats like olive or rapeseed oil .

Patients should eat at least 5 portions of fruit and vegetables daily and at least 2 portions of fish weekly, with pregnant women advised to limit oily fish to 2 portions per week .

They should be advised that food products containing stanols and sterols need to be taken consistently to be effective if they wish to consume them .

It is recommended that they do not routinely take omega-3 fatty acid supplements .

Patients should be supported to achieve and maintain a healthy weight if overweight or obese, and to limit alcohol intake to up to 3-4 units per day for men and 2-3 units for women, avoiding binge drinking .

Strong encouragement should be given to avoid smoking, and support should be offered to stop smoking, including referral to support services or pharmacotherapy if needed .

Educational content only. Always verify information and use clinical judgement.

What lifestyle modifications should I advise to patients with familial