What are the contraindications for prescribing HRT that I should be aware of in my practice?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Contraindications for prescribing hormone replacement therapy (HRT) include a personal history of breast cancer or high risk of breast cancer, where HRT should not be routinely offered and referral to a specialist is recommended .

HRT should be stopped in women diagnosed with breast cancer, in line with NICE guidelines .

HRT is contraindicated in individuals with hormone-sensitive cancers or conditions where hormones may exacerbate the condition, and advice should be sought from a healthcare professional with expertise in the condition .

Women with contraindications to hormonal treatments should be advised accordingly, including those with certain medical conditions that may be affected by HRT .

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What are the contraindications for prescribing HRT that I should be aw