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How should I approach the management of dermatomyositis in a patient with associated malignancy?

Answer

Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 16 August 2025

The management of dermatomyositis in a patient with an associated malignancy requires a dual approach, focusing on both the myositis and the underlying cancer (Selva-O'Callaghan et al., 2022). A crucial aspect of this management is the identification and treatment of the associated malignancy, as addressing the cancer can often lead to an improvement in the dermatomyositis symptoms (Selva-O'Callaghan et al., 2022). Therefore, general principles for the recognition and referral of suspected cancer should be followed to ensure timely diagnosis of the underlying malignancy 6. If metastatic malignant disease is present, its management should adhere to established guidelines 4. Alongside cancer treatment, immunosuppressive therapies are typically employed to manage the symptoms of dermatomyositis itself (Selva-O'Callaghan et al., 2022).

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