What are the recommended first-line treatments for managing an acute exacerbation of COPD in primary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In primary care, the recommended first-line treatments for managing an acute exacerbation of COPD include:

  • Increasing the doses or frequency of short-acting bronchodilators, using the same delivery system as usual, such as inhalers, spacers, or nebulizers, depending on the patient's ability and resources available ().
  • Considering oral corticosteroids, specifically offering 30 mg of oral prednisolone once daily for 5 days, if there are no contraindications and the patient has a significant increase in breathlessness that interferes with daily activities ().

Related Knowledge Topics

Educational content only. Always verify information and use clinical judgement.