What are the indications for surgical intervention in patients diagnosed with cholesteatoma?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Surgical intervention is the primary and only curative treatment for cholesteatoma . The extent of the cholesteatoma lesion determines the specific type of surgery required . For instance, mastoidectomy may be necessary if there is extensive disease .

Urgent surgical intervention is indicated in patients presenting with suspected cholesteatoma who also exhibit signs of serious or life-threatening complications . These include an associated facial nerve palsy, neurological symptoms or signs, or if the patient is systemically unwell, as these may suggest more extensive or advanced disease . Clinical features indicative of complications such as acute mastoiditis, intracranial abscess, or meningitis also necessitate urgent hospital admission or specialist ENT advice, often leading to surgical management . Delayed treatment in cases with facial nerve palsy is associated with a poor prognosis .

For all patients diagnosed with cholesteatoma, prompt referral to an Ear, Nose, and Throat (ENT) specialist is arranged for further assessment, confirmation of the diagnosis, and consideration of surgical intervention . High-resolution CT imaging of the temporal bone is often used to define the extent of the cholesteatoma, identify bony erosion, and assess for other complications, which guides surgical planning . Endoscopic management is also a recognized surgical approach for primary acquired cholesteatoma .

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