What are the key clinical features that differentiate viral conjunctivitis from bacterial conjunctivitis in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In a primary care setting, the differentiation between viral and bacterial conjunctivitis, based on the provided guidelines, primarily involves their typical resolution times and the appropriateness of antibiotic treatment.

  • Resolution Time: Acute viral (non-herpetic) conjunctivitis usually resolves within one to two weeks without antimicrobial treatment . In contrast, acute bacterial conjunctivitis typically resolves within 5–7 days without treatment .
  • Antibiotic Use: Topical antibiotics are generally not appropriate for viral conjunctivitis and may cause adverse reactions . For bacterial conjunctivitis, while often self-limiting, topical antibiotics may be considered if the condition is severe, if rapid resolution is required, or as a delayed treatment strategy if symptoms have not resolved within 3 days .
  • Contagiousness Duration: Individuals with viral conjunctivitis may be infectious for up to 14 days from the onset of symptoms .

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