What follow-up testing is recommended after treatment for H. pylori to confirm eradication?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Re-testing for Helicobacter pylori after treatment should be performed at least 4–8 weeks post-therapy, using a carbon-13 urea breath test as the first-line option, or a stool antigen test if the breath test is unavailable, ensuring the patient has not taken PPIs in the past 2 weeks or antibiotics in the past 4 weeks .

If re-testing is positive, second-line eradication therapy should be prescribed .

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