What follow-up protocols should I implement for patients treated for Conn's syndrome to monitor for complications or recurrence?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Follow-up protocols for patients treated for Conn's syndrome (primary hyperaldosteronism) should include:

  • Regular monitoring of blood pressure to assess control and detect hypertension recurrence.
  • Periodic measurement of serum electrolytes, especially potassium, to identify hypokalaemia or electrolyte imbalances.
  • Assessment of renal function through estimated glomerular filtration rate (eGFR) or serum creatinine, as renal impairment can be a complication.
  • Annual measurement of serum aldosterone and renin levels may be considered to monitor biochemical recurrence, although specific intervals should be guided by specialist advice.
  • Cardiovascular risk assessment and management, given the increased risk associated with aldosterone excess.
  • Imaging or specialist referral if clinical or biochemical signs suggest recurrence or complications.
  • Coordination of care between primary and secondary care, with re-referral to endocrinology if symptoms recur or biochemical abnormalities persist.

These follow-up measures aim to detect recurrence of hyperaldosteronism, manage hypertension, prevent cardiovascular and renal complications, and ensure optimal long-term outcomes for patients treated for Conn's syndrome.

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