Which specific referral criteria should I follow for patients with suspected head and neck cancer according to NICE guidelines?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Consider a suspected cancer pathway referral for laryngeal cancer in people aged 45 and over with persistent unexplained hoarseness or an unexplained lump in the neck .

Consider a suspected cancer pathway referral for oral cancer in people with either unexplained ulceration in the oral cavity lasting more than 3 weeks or a persistent and unexplained lump in the neck .

Consider a suspected cancer pathway referral for oral cancer in people when assessed by a dentist as having a lump on the lip or in the oral cavity, or a red or red and white patch in the oral cavity consistent with erythroplakia or erythroleukoplakia .

Consider a suspected cancer pathway referral for penile cancer in men if they have a penile mass or ulcerated lesion, when sexually transmitted infection has been excluded or a persistent penile lesion after treatment for an STI .

Consider a suspected cancer pathway referral for penile cancer in men if they have unexplained or persistent symptoms affecting the foreskin or glans .

Educational content only. Always verify information and use clinical judgement.