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What are the potential complications of GPA that I should be aware of when managing patients in primary care?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 16 August 2025
When managing patients with granulomatosis with polyangiitis (GPA) in primary care, it is important to be aware that GPA is a form of vasculitis, previously known as Wegener granulomatosis (Frankel et al., 2002). A significant potential complication to be aware of is lung involvement, as this is a common feature in ANCA-associated vasculitis, which includes GPA (Sacoto et al., 2020).
Key References
- CKS - Giant cell arteritis
- CG150 - Headaches in over 12s: diagnosis and management
- NG78 - Cystic fibrosis: diagnosis and management
- (Frankel et al., 2002): Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis.
- (Sacoto et al., 2020): Lung involvement in ANCA-associated vasculitis.
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