What are the recommended first-line treatments for managing Graves' disease in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Offer radioactive iodine as first-line definitive treatment for adults with Graves' disease, unless antithyroid drugs are likely to achieve remission or are unsuitable .

Offer a choice of antithyroid drugs (a 12- to 18-month course) or radioactive iodine as first-line definitive treatment if antithyroid drugs are likely to achieve remission .

Offer antithyroid drugs (a 12- to 18-month course) as first-line definitive treatment for adults with Graves' disease if radioactive iodine and surgery are unsuitable .

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