What are the indications for systemic therapies in the management of severe atopic eczema?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Consider systemic therapies for severe atopic eczema in children when other management options have failed or are inappropriate, and there is a significant negative impact on quality of life .

Systemic therapy should only be used under specialist dermatological supervision by staff experienced in working with children .

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