What are the recommended first-line pharmacological treatments for adults diagnosed with ADHD?

Offer lisdexamfetamine or methylphenidate as first-line pharmacological treatment for adults with ADHD ¹.

Consider switching to lisdexamfetamine for adults who have had a 6-week trial of methylphenidate at an adequate dose but have not derived enough benefit in terms of reduced ADHD symptoms and associated impairment ¹.

Consider switching to methylphenidate for adults who have had a 6-week trial of lisdexamfetamine at an adequate dose but have not derived enough benefit ¹.

Consider dexamfetamine for adults whose ADHD symptoms are responding to lisdexamfetamine but who cannot tolerate the longer effect profile ¹.

Offer atomoxetine to adults if they cannot tolerate lisdexamfetamine or methylphenidate, or if their symptoms have not responded to separate 6-week trials of these medications ¹.