What are the referral criteria for a suspected case of ALL to a specialist haematology service?

For a suspected case of acute lymphoblastic leukaemia, a **very urgent full blood count (within 48 hours)** should be offered in children and young people ¹.

Bone pain that is persistent or unexplained in children and young people warrants consideration for urgent investigation, including blood tests ¹.

In cases with unexplained lymphadenopathy, splenomegaly, or weight loss in children and young people, a very urgent referral for specialist assessment is recommended ¹.

Any neurological symptoms, such as newly abnormal cerebellar or other central neurological function, should prompt a very urgent referral within 48 hours ¹.

Consider a very urgent referral for children and young people presenting with symptoms suggestive of leukaemia, such as unexplained bone pain, lymphadenopathy, splenomegaly, or neurological symptoms ¹.