Which initial investigations are recommended for confirming a diagnosis of ALL in primary care?

In primary care, investigations are primarily aimed at identifying suspected cases of acute lymphoblastic leukaemia (ALL) to facilitate urgent referral, rather than confirming the diagnosis [1. 10. 2, 1. 10. 3]. For children and young people with unexplained bleeding or bruising, or generalised lymphadenopathy, a very urgent full blood count (within 48 hours) is recommended [1. 10. 3]. If unexplained hepatosplenomegaly or petechiae are present, an immediate specialist assessment is recommended [1. 10. 2]. Definitive diagnostic investigations for confirming ALL are conducted by specialists following these urgent referrals [1. 10. 2, 1. 10. 3].