Which risk factors should I assess in patients with a history of stroke to guide their long-term management?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In patients with a history of stroke, the key risk factors to assess for guiding long-term management include:

  • Hypertension: Blood pressure control is critical as 50–80% of stroke patients have hypertension, and treatment is highly effective in secondary prevention .
  • Atrial fibrillation (AF): Screen for AF as anticoagulation is recommended for secondary prevention in people with paroxysmal or permanent AF .
  • Diabetes mellitus: Glycaemic control should be individualized, aiming for HbA1c ≤7% in most patients under 65 without life-limiting comorbidities, using agents with cardiovascular benefit .
  • Obstructive sleep apnoea: Screen using validated tools and refer for specialist assessment if suspected, as treatment with CPAP is recommended .
  • Lipid levels: Assess and manage dyslipidaemia with high-intensity statin therapy to reduce vascular risk .
  • Smoking status: Assess smoking and offer cessation support, including referral to NHS Stop Smoking Services .
  • Obesity: Assess weight and refer to weight management services if appropriate .
  • Contraception and hormone therapy in women: Avoid combined oral contraceptives in premenopausal women with stroke history due to increased risk; consider progestogen-only or non-hormonal methods .
  • Medication adherence and side effects: Review secondary prevention medications including antiplatelets, anticoagulants, and statins, ensuring patient understanding and adherence .

These assessments should be part of regular follow-up at 6 months post-discharge and then annually to review ongoing risk factors and secondary prevention .

Educational content only. Always verify information and use clinical judgement.