Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX
To confirm a diagnosis of Multiple Sclerosis (MS) in suspected cases, investigations are performed by a consultant neurologist or a specialist under their supervision NICE NG220. The diagnosis is established using a combination of history, examination, MRI, and laboratory findings, adhering to the 2017 revised McDonald criteria NICE NG220.
- This diagnostic process involves assessing that symptoms are consistent with an inflammatory demyelinating process NICE NG220.
- It also includes excluding alternative diagnoses, with targeted laboratory tests potentially indicated if the history, examination, or MRI findings are atypical NICE NG220.
- For a diagnosis of relapsing-remitting MS, it is necessary to establish that lesions on MRI scans have developed at different times and are in different anatomical locations NICE NG220.
- Cerebrospinal fluid-specific oligoclonal bands should be sought if there is no clinical or radiological evidence of lesions developing at different times NICE NG220.
- For a diagnosis of primary progressive MS, progressive neurological deterioration over one year or more must be established NICE NG220.
It is important to note that MS should not be diagnosed based on MRI findings alone NICE NG220.