What are the key clinical features to assess in a patient presenting with knee pain to differentiate between osteoarthritis and meniscal injury?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

To differentiate between osteoarthritis (OA) and a meniscal injury in a patient presenting with knee pain, a thorough clinical assessment focusing on history and examination findings is crucial .

Key features for Osteoarthritis (OA):

  • A clinical diagnosis of knee OA can often be made without imaging if the patient is 45 years or older, has activity-related joint pain, and has either no morning joint stiffness or morning stiffness lasting no longer than 30 minutes .
  • Pain is typically activity-related and worsens with use .
  • Stiffness is commonly experienced in the morning, lasting less than 30 minutes, or after periods of rest .
  • Patients may report reduced function and difficulty with daily activities .
  • On examination, crepitus (a grating or crackling sound) may be felt or heard during knee movement . An effusion (swelling due to fluid accumulation) may also be present .

Key features for Meniscal Injury:

  • A history of a specific twisting injury to the knee is often reported .
  • Patients commonly present with mechanical symptoms such as locking (the knee getting stuck), clicking, or giving way (sudden instability) .
  • Pain is often exacerbated by specific movements like squatting .
  • On examination, there may be tenderness along the joint line where the meniscus is located . An effusion may also be present .

Differentiation and Overlap:

  • The presence of mechanical symptoms like locking, clicking, or giving way is highly suggestive of a meniscal injury and helps differentiate it from isolated OA .
  • While OA pain is typically more generalized and activity-related, meniscal pain can be more localized to the joint line and triggered by specific movements ,.
  • Morning stiffness lasting less than 30 minutes is a hallmark of OA, whereas it is less characteristic of an isolated meniscal injury .
  • It is important to note that individuals can present with both osteoarthritis and symptomatic meniscal tears, which can collectively influence their reported pain and mobility [Luc-Harkey et al., 2018]. Therefore, a comprehensive assessment is vital to identify all contributing factors to the patient's knee pain .

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