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What are the key clinical features to assess in a patient presenting with knee pain to differentiate between osteoarthritis and meniscal injury?

Answer

Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 14 August 2025

To differentiate between osteoarthritis (OA) and a meniscal injury in a patient presenting with knee pain, a thorough clinical assessment focusing on history and examination findings is crucial 2.

Key features for Osteoarthritis (OA):

  • A clinical diagnosis of knee OA can often be made without imaging if the patient is 45 years or older, has activity-related joint pain, and has either no morning joint stiffness or morning stiffness lasting no longer than 30 minutes 1.
  • Pain is typically activity-related and worsens with use 1.
  • Stiffness is commonly experienced in the morning, lasting less than 30 minutes, or after periods of rest 1.
  • Patients may report reduced function and difficulty with daily activities 1.
  • On examination, crepitus (a grating or crackling sound) may be felt or heard during knee movement 2. An effusion (swelling due to fluid accumulation) may also be present 2.

Key features for Meniscal Injury:

  • A history of a specific twisting injury to the knee is often reported 2.
  • Patients commonly present with mechanical symptoms such as locking (the knee getting stuck), clicking, or giving way (sudden instability) 2.
  • Pain is often exacerbated by specific movements like squatting 2.
  • On examination, there may be tenderness along the joint line where the meniscus is located 2. An effusion may also be present 2.

Differentiation and Overlap:

  • The presence of mechanical symptoms like locking, clicking, or giving way is highly suggestive of a meniscal injury and helps differentiate it from isolated OA 2.
  • While OA pain is typically more generalized and activity-related, meniscal pain can be more localized to the joint line and triggered by specific movements 1,2.
  • Morning stiffness lasting less than 30 minutes is a hallmark of OA, whereas it is less characteristic of an isolated meniscal injury 1.
  • It is important to note that individuals can present with both osteoarthritis and symptomatic meniscal tears, which can collectively influence their reported pain and mobility [Luc-Harkey et al., 2018]. Therefore, a comprehensive assessment is vital to identify all contributing factors to the patient's knee pain 2.

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This content was generated by iatroX. Always verify information and use clinical judgment.