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What are the recommended first-line treatments for an acute gout attack in adults?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 14 August 2025
Offer a non-steroidal anti-inflammatory drug (NSAID), colchicine or a short course of an oral corticosteroid for first-line treatment of a gout flare, taking into account the person's comorbidities, co-prescriptions and preferences 1.
Use a maximum dose of NSAID, such as naproxen, and continue treatment until 1-2 days after symptoms resolve 1.
Consider a short course of oral corticosteroid, for example prednisolone 30-35 mg once a day for 3-5 days 1.
Consider intra-articular or intramuscular corticosteroid injections if NSAIDs and colchicine are not tolerated or are ineffective 1.
Advise ice packs to the affected joint to help alleviate pain 1.
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