What are the key clinical features to consider when diagnosing Systemic Lupus Erythematosus (SLE) in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When considering systemic lupus erythematosus (SLE) in a primary care setting, it is crucial for primary care physicians to be aware of its diverse and sometimes unusual presentations [Pramanik, 2014]. Knowledge of these varied manifestations is essential to aid in diagnosis [Pramanik, 2014]. Furthermore, identifying risk factors and understanding pathways for clinical care are important considerations that can contribute to early recognition of SLE [Choi et al., 2016].

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